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These subpharmacologicaldoses are not expected to produce any therapeutic or toxiceffects, but yield human pharmacokinetic information. Updating the information on aregular basis is essential to ensure the patient is progressing toward accomplishing the treatmentgoals outlined in the POC. Drug therapy: Medical treatment of periph-eral arterial disease and claudication. Because of the time taken to induceprotein synthesis, aldosterone action has a latencyof 1–2 hours. This chapter reviewseach from initial discovery to our current understanding of their deregulation inhuman cancer with a focus on how each regulator impacts p53 function. As mentioned earlier when discussing mitochondrial-induced apoptosis, members ofthe BCL-2 family also control the lifespan of DC because signals from BCL-2 can block theactivation of the death regulator BIM (Nopora 2001). In Goldstein N, Morrison S,eds., Evidence-Based Practice of Palliative Medicine. Clin Dev Immunol, 2008: 723539.Miller, R.A., Harrison, D.E., Astle, C.M., et al.

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